Novel Moxifloxacin Ion Selective Electrodes for Potentiometric Determination of Moxifloxacin in Pure Form and Pharmaceutical Formulations
دكتور هاشم ضبيط
ملخص البحث:
Moxifloxacin (MFX) is a synthetic broad-spectrum bactericidal 4th generation fluoroquinolone. At this study, three PVC membrane ion selective electrodes were constructed for MFX analysis purposes. The electro-active materials are MFX-tetraphenyl borate (MFX-TPB), MFX-Reineckate (MFX-RNK) or MFX-Nessler’s (MFX-NSR). The characterization and analytical properties were determined. The casting membranes were plasticized by di-n-butyl phthalate (DBP). The constructed electrodes have inner reference Ag/AgCl electrode. In addition, the assembled sensors have outer reference Ag/AgCl electrode. The sensors were near Nernstian response when the percentages ion pair at membranes were 6%, 4%, 6% for MFX-TPB, MFX-RNK, and MFX-NSR, respectively. The electrodes exhibited a fast dynamic response of 14-21 sec for a period of 10-13 days, without significant change in the electrodes parameters. The sensors worked at pH ranges 2.0-5.0, 2.0-5.5, and 2.0-6.0 for MFX-TPB, MFX-RNK, MFX-NSR sensors, respectively. The sensors have been used as indicator electrodes for direct determination of MFX in pharmaceutical preparations with mean relative standard deviation less than 2% indicating good precision, as well as in pure form solutions with average recovery of 98.58%, 99.09%, 99.27% and a mean relative standard deviation of 1.28, 1.81 and 1.91% at 0.438μg/ml MFX•HCl for MFX-TPB, MFX-RNK, and MFX-NSR sensors respectively
اسم المجلة التي نشر فيها البحث:
International Journal of Academic Scientific Research (IJASR).
تاريخ النشر:
2015.